Adaptive Spinning-Disk Interferometry for Biomolecule Detection
- Resource Type
- Authors
- H. Dorota Inerowicz; Manoj M. Varma; David D. Nolte; Leilei Peng; Fred E. Regnier
- Source
- Photorefractive Effects, Materials, and Devices.
- Subject
- Wavefront
chemistry.chemical_classification
business.industry
Biomolecule
Compact disc
Photorefractive effect
STRIPS
law.invention
Interferometry
Optics
Homodyne detection
chemistry
law
business
Phase modulation
- Language
We have identified a potential candidate for a high-throughput multi-analyte assay based on the optical compact disk (CD) in conjunction with adaptive homodyne detection using photorefractive quantum wells, and have succeeded in initial system tests that show our current ability to detect strips of immobilized molecules on a spinning disk of approximately 5 nm height. With the possibility of an improvement of nearly 100, this technique will be able to detect antibodies and antibody/antigen binding in immunological assays.