Microarray platforms for enzymatic and cell-based assays
- Resource Type
- Authors
- Mark Bradley; Guilhem Tourniaire; Juan J. Díaz-Mochón
- Source
- Chemical Society reviews. 36(3)
- Subject
- chemistry.chemical_classification
Proteases
Microarray
Chemistry
Kinase
Computer science
Nanotechnology
General Medicine
General Chemistry
Computational biology
Cell based assays
Enzymes, Immobilized
Microarray Analysis
Enzyme
ComputingMethodologies_PATTERNRECOGNITION
Gene chip analysis
Protein microarray
Substrate specificity
Animals
Humans
Peptide microarray
DNA microarray
Kinase activity
Cells, Cultured
- Language
- ISSN
- 0306-0012
This tutorial review introduces the uninitiated to the world of microarrays (or so-called chips) and covers a number of basic concepts such as substrates and surfaces, printing and analysis. It then moves on to look at some newer applications of microarray technology, which include enzyme analysis (notably kinases and proteases) as well as the growing enchantment with so-called cell-based microarrays that offer a unique approach to high-throughput cellular analysis. Finally, it looks forwards and highlights future possible trends and directions in the microarray arena.