Multiplex Biomarker Approaches in Type 2 Diabetes Mellitus Research
- Resource Type
- Authors
- Ozanne, Susan E; Rahmoune, Hassan; Guest, Paul C
- Source
- Subject
- Proteomics
Drug targets
Genomics
Prognosis
Risk Assessment
Epigenesis, Genetic
Diabetes Complications
Diabetes Mellitus, Type 2
Type 2 diabetes mellitus
Drug Discovery
Metabolomics
Humans
Disease Susceptibility
Biomarkers
- Language
Type 2 diabetes mellitus is a multifactorial condition resulting in high fasting blood glucose levels. Although its diagnosis is straightforward, there is not one set of biomarkers or drug targets that can be used for classification or personalized treatment of individuals who suffer from this condition. Instead, the application of multiplex methods incorporating a systems biology approach is essential in order to increase our understanding of this disease. This chapter reviews the state of the art in biomarker studies of human type 2 diabetes from a proteomic and metabolomic perspective. Our main focus was on biomarkers for disease prediction as these could lead to early intervention strategies for the best possible patient outcomes.