Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir
- Resource Type
- Authors
- Sandra Karall; Julia C. Schwarz; Victoria Klang; Denise Mahrhauser; Claudia Valenta; Guenter P. Resch
- Source
- International Journal of Pharmaceutics. 435:69-75
- Subject
- Materials science
Chromatography
Stripping (chemistry)
Swine
Dispersity
Acyclovir
Pharmaceutical Science
Nanoparticle
Permeation
Administration, Cutaneous
Microstructure
Antiviral Agents
Drug Stability
Chemical engineering
Spectroscopy, Fourier Transform Infrared
medicine
Animals
Nanoparticles
Emulsions
Aciclovir
Phase inversion
Diffusion cell
Skin
medicine.drug
- Language
- ISSN
- 0378-5173
In the present study multiple W/O/W nanoemulsions were optimised for the dermal application of the antiviral drug aciclovir. The phase inversion temperature method was employed to prepare the formulations without the input of high pressure. During formulation design the ethoxylated surfactants were varied and if possible partly replaced by natural sugar surfactants. Multiple nanoemulsions with mean droplet sizes around 100 nm and polydispersity indices below 0.1 were prepared. At room temperature, they exhibited excellent physicochemical stability over an observation period of 6 months. Furthermore, cryo electron microscopy gave an insight into the microstructure of the multiple nanoemulsions. Moreover, the formulations' interaction with skin was analysed by ATR-FTIR. In Franz-type diffusion cell and tape stripping experiments aciclovir showed satisfying skin permeation from the novel nanoemulsions.