6-Benzyloxyphthalides as selective and reversible monoamine oxidase B inhibitors with antioxidant and anti-neuroinflammatory activities for Parkinson’s disease treatment
- Resource Type
- Authors
- Qing, Song; Guangjun, Yu; Wei, Li; Yidan, Xu; Shiqin, Cong; Xiuxiu, Liu; Zhenghuai, Tan; Yong, Deng
- Source
- Bioorganic Chemistry. 120:105623
- Subject
- Mice
Structure-Activity Relationship
Monoamine Oxidase Inhibitors
Dopamine Agents
Organic Chemistry
Drug Discovery
Animals
Parkinson Disease
Prospective Studies
Monoamine Oxidase
Molecular Biology
Biochemistry
Antioxidants
- Language
- ISSN
- 0045-2068
A series of 6-benzyloxyphthalides were designed and synthesized as potent monoamine oxidase B inhibitors with antioxidant and anti-neuroinflammatory activities. The representative compounds 8f and 14a exhibited excellent selective MAO-B inhibition activity (IC