Antiplasmodial activity of harmirins – novel harmine – coumarin hybrids
- Resource Type
- Authors
- Pavić, Kristina; Rajić, Zrinka; Pessanha de Carvalho, Lais; Held, Jana
- Source
- Macedonian Pharmaceutical Bulletin. 68:407-408
- Subject
- Geography, Planning and Development
harmine
coumarin
malaria
Plasmodium
Development
- Language
- ISSN
- 1857-8969
1409-8695
Harmirins are hybrid compounds comprising both harmine and coumarin pharmacophores linked by 1, 2, 3-triazole. We have evaluated in vitro antiplasmodial activity against the erythrocytic stage of P. falciparum of five series of harmirins. Compound 12b showed the highest activity against the tested P. falciparum strains and the lowest cytotoxicity against non-cancer cell line Hek293.