Carrie Tompkins Stricker, PhD, RN, AOCN, is an oncology nurse practitioner in the Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, and the Chief Clinical Officer and cofounder of On Q Health, Inc., Miami, FL. This is an exciting and challenging time in which to care for women at risk for, with a diagnosis of, or a history of breast cancer. Scientific advances in cancer genetics and immunology have resulted in dramatic increases in the number and complexity of treatment options available to these women, and these treatment options have led to significant improvements in survival rates and length of survival. Advances in the state of multidisciplinary science, including nursing research, have informed the management of critical aspects of patient care along the illness continuum. The authors of the articles in this In Focus series highlight three of these areas: genetic predisposition to breast cancer, pregnancy and fertility concerns of breast cancer survivors, and late/long-term effects from breast cancer therapies and disease surveillance.