Elevated Tryptase in EoE Is an Independent Phenomenon Associated with Extra-Esophageal Symptoms
- Resource Type
- Authors
- Kathryn A. Peterson; Geeta R. Kutty; Erinn Downs-Kelly; Hilda T. Crispin
- Source
- Digestive Diseases and Sciences. 64:152-157
- Subject
- Adult
Male
medicine.medical_specialty
Adolescent
Physiology
Tryptase
Comorbidity
Severity of Illness Index
Gastroenterology
Atopy
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Eosinophilic
medicine
Humans
Eosinophilia
Mast Cells
Eosinophilic esophagitis
Sinusitis
Retrospective Studies
Asthma
biology
business.industry
Eosinophilic Esophagitis
Middle Aged
Eosinophil
Prognosis
medicine.disease
Up-Regulation
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Female
Tryptases
030211 gastroenterology & hepatology
medicine.symptom
business
Biomarkers
- Language
- ISSN
- 1573-2568
0163-2116
Eosinophilic esophagitis (EoE) is a chronic disease characterized histologically by > 15 eosinophils per high-power field (eos/hpf). Esophageal mucosal mast cells have been implicated in EoE pathogenesis. The association of atopy with EoE has been established but has not been correlated with levels of serum tryptase. The lack of concurrent atopy in some patients suggests the possibility that atopy may either be the related subtype of EoE or may be a sign of comorbidities. No study has looked at whether patients present with different phenotypes/comorbid disease when they have evidence of elevated serum tryptase. We hypothesized that these patients differ with respect to presentation and comorbidities with more refractory GI disease. To examine whether elevations of serum tryptase associate with different, more severe clinical presentations in EoE patients which may be explained via mast cell activation. Retrospective chart review identified 72 patients with EoE with results for serum tryptase between 2015 and 2016. Patients were classified as TryptaseHI (tryptase > 10.9 µg/l) and TryptaseLO (