Periodontitis is a chronic infectious disease caused by dental plaque bacterial biofilm. This biofilm leads to the destruction of connective tissue with inflammation and the destruction of alveolar bone by creating a pocket and over time leads to tooth loss. Many types of studies have shown that both type 1 and type 2 diabetes mellitus develop the prevalence and intensity of periodontitis, and that the effects are more obvious in type 2 diabetes patients. Poor glycemic control has been considered a serious risk factor for periodontitis. The prevalence and intensity of periodontitis in type 2 diabetes patients have been reported to be enhancements because chronic hyperglycemia (long-term poor glycemic control) increases host sensitivity to infectious bacteria in the periodontium. Diabetic microangiopathic change has been also propounded as a risk factor for periodontitis. Poor blood sugar control in the long-term causes microangiopathic changes such as retinopathy, nephropathy, and neuropathy and macroangiopathic changes such as coronary artery disease, peripheral artery disease, and stroke as morphological changes in type 2 diabetic patients. in the same way, such changes to the periodontal tissue can increase host sensitivity to infectious bacteria in the periodontium.