Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga-gallgas in patients with chronic obstructive pulmonary disease: A pilot study
- Resource Type
- Authors
- Gabriel Adrián González; Eduardo Savio; Liliana Servente; Juan Pablo Gambini; Henry Engler; Omar Alonso; Enrique Gustavo Cuña
- Source
- World Journal of Nuclear Medicine, Vol 18, Iss 3, Pp 251-257 (2019)
COLIBRI
Universidad de la República
instacron:Universidad de la República
- Subject
- lcsh:Medical physics. Medical radiology. Nuclear medicine
Gallgas
medicine.diagnostic_test
business.industry
lcsh:R895-920
Pulmonary disease
technegas
Single-photon emission computed tomography
Pearson product-moment correlation coefficient
quantification
symbols.namesake
Positron emission tomography
Quantification
SPECT Lung ventilation
symbols
medicine
In patient
texture features
Nuclear medicine
business
Lung ventilation
Technegas
Texture features
- Language
- English
- ISSN
- 1607-3312
1450-1147
The aim of this study was quantitative comparison between 68Ga-Gallgas positron emission tomography (PET) and 99mTc-Technegas single photon emission computed tomography (SPECT) for lung ventilation function assessment in patients with moderate-to-severe obstructive pulmonary disease and to identify image-derived texture features correlating to the physiologic parameters. Five patients with moderate-to-severe chronic obstructive pulmonary disease with PET and SPECT lung ventilation scans were selected for this study. Threshold-based segmentations were used to compare ventilated regions between both imaging techniques. Histograms of both scans were compared to reveal main differences in distributions of radiotracers. Volumes of segmentation as well as 50 textural features measured in the pulmonary region were correlated to the forced expiratory volume in 1 s (FEV1) as the relevant physiological variable. A better peripheral distribution of the radiotracer was observed in PET scans for three out of five patients. A segmentation threshold of 27% and 31% for normalized scans, for PET and SPECT respectively, was found optimal for volume correlation with FEV1. A high correlation (Pearson correlation coefficient >0.9) was found between 16 texture features measured from SPECT and 7 features measured from PET and FEV1. Quantitative measurements revealed different tracer distribution in both techniques. These results suggest that tracer distribution patterns may depend on the cause of the pulmonary obstruction. We found several texture features measured from SPECT to correlate to FEV1.