Feasibility and safety of peripheral blood stem cell collection in children with poor-prognosis solid tumors: a single center experience
- Resource Type
- Authors
- I. Dolgopolov; M. Yankelevich; L. Andreeva; D. Ijoguine; Stuart E. Siegel; D. Mscheidze; G. Mentkevich
- Source
- Pediatric hematology and oncology. 16(4)
- Subject
- Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Urology
CD34
Blood volume
Single Center
Blood cell
White blood cell
Neoplasms
Granulocyte Colony-Stimulating Factor
medicine
Humans
Leukapheresis
Child
Chemotherapy
business.industry
Granulocyte-Macrophage Colony-Stimulating Factor
Infant
Hematology
Prognosis
Hematopoietic Stem Cell Mobilization
Granulocyte colony-stimulating factor
Surgery
medicine.anatomical_structure
Oncology
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
business
- Language
- ISSN
- 0888-0018
This study reports the data of 32 children with poor-prognosis solid tumors who had 78 PBSC harvests on Fenwall CS-3000plus after mobilization mainly by different treatment protocol chemotherapy regimens followed by G- or GM-CSF (92% of patients) or by G-/GM-CSF alone (8%). Timing of procedure was predicted by studying the blood count. When the white blood cell and platelet count reached a median of 8.1 (0.9-37.3) and 95 (16-338) x 10(9)/L, respectively, the median number of 2.7 (0.005-16.8) x 10(6) CD34+/kg with 1.5 (0.005-11.6) x 10(6) CD34+/kg for 1 blood volume processed was obtained per procedure. In the group of 13 patients with low body weight (median 14 [10-20] kg) 32 leukophereses were performed. The extracorporal line was primed with donor red blood cells in the patients with the weight below 15 kg. No difference was observed in CD34+ content in harvests whether GM-CSF was begun on day +1 or on day +3 after chemotherapy.