Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition
- Resource Type
- Authors
- Kazuhiro Ito; Christos Rossios; Misako Ito; Y To; G Osoata; Peter J. Barnes
- Source
- British Journal of Pharmacology. 167:775-786
- Subject
- Pharmacology
Budesonide
COPD
medicine.medical_specialty
medicine.drug_class
Chemistry
medicine.disease
medicine.disease_cause
Endocrinology
Internal medicine
medicine
Corticosteroid
Formoterol Fumarate
Formoterol
Salmeterol
hormones, hormone substitutes, and hormone antagonists
Dexamethasone
Oxidative stress
medicine.drug
- Language
- ISSN
- 0007-1188
BACKGROUND AND PURPOSE Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids, which has been linked to oxidative stress. Here we show that the long-acting β2-agonist formoterol (FM) reversed corticosteroid insensitivity under oxidative stress via inhibition of phosphoinositide-3-kinase (PI3K) signalling.