Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE)
- Resource Type
- Authors
- Robert Lucht; Michael G. Hennerici; Friedemann Gückel; Wolfgang Neff; Gunnar Brix; Christine Ueltzhöffer
- Source
- European Radiology. 17:2483-2490
- Subject
- Male
Pathology
medicine.medical_specialty
Perfusion scanning
Blood volume
Grey matter
Microcirculation
White matter
Internal medicine
parasitic diseases
medicine
Humans
Radiology, Nuclear Medicine and imaging
Aged
Blood Volume
medicine.diagnostic_test
business.industry
Dementia, Vascular
Magnetic resonance imaging
General Medicine
Magnetic Resonance Imaging
medicine.anatomical_structure
Cerebral blood flow
Cerebrovascular Circulation
Cardiology
Female
Radiology
Functional magnetic resonance imaging
business
- Language
- ISSN
- 1432-1084
0938-7994
The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy volunteers were examined. Using a well-established dynamic susceptibility contrast-enhanced MRI method, the regional cerebral blood flow (rCBF) and blood volume (rCBV) were quantified for each subject in 12 different regions in the brain parenchyma. As compared to healthy volunteers, patients with SAE showed significantly reduced rCBF and rCBV values in white matter regions and in the occipital cortex. Regions containing predominantly grey matter show almost normal rCBF and rCBV values. In conclusion, quantitative analysis of rCBF and rCBV values demonstrates clearly that SAE is a disease that is associated with a reduced microcirculation predominantly in white matter.