Monitoring neonatal fungal infection with metabolomics
- Resource Type
- Authors
- Vassilios Fanos; Marco Zaffanello; Angelica Dessì; Mario Giuffrè; Mauro Stronati; Antonio Noto; Pierluigi Caboni; Giovanni Corsello; Francesca Serraino; Barbara Liori
- Source
- The Journal of Maternal-Fetal & Neonatal Medicine. 27:34-38
- Subject
- Fungal infection
medicine.medical_specialty
Urine
Infant, Newborn, Diseases
sepsis
Sepsis
Settore MED/38 - Pediatria Generale E Specialistica
Metabolomics
Intensive Care Units, Neonatal
medicine
Humans
Intensive care medicine
Principal Component Analysis
Patient affected
business.industry
Infant, Newborn
Obstetrics and Gynecology
medicine.disease
Italy
Mycoses
fungal infections
Pediatrics, Perinatology and Child Health
Metabolome
Population study
Metabolomic
Prematurity
Fungal sepsis
Clinical case
neonate
business
Biomarkers
Metabolic profile
metabolomic
- Language
- ISSN
- 1476-4954
1476-7058
The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.