Toxic epidermal necrolysis successfully treated with etanercept
- Resource Type
- Authors
- Emanuela Gubinelli; Desanka Raskovic; Tiziano Tonanzi; Flora Canzona; Biagio Didona
- Source
- The Journal of dermatology. 36(3)
- Subject
- medicine.medical_specialty
Time Factors
integumentary system
business.industry
Tumor Necrosis Factor-alpha
Dermatology
General Medicine
Middle Aged
medicine.disease
Toxic epidermal necrolysis
Receptors, Tumor Necrosis Factor
Etanercept
Immunoglobulin G
Stevens-Johnson Syndrome
medicine
Effective treatment
Humans
Female
Adverse effect
business
medicine.drug
- Language
- ISSN
- 1346-8138
Toxic epidermal necrolysis (TEN) is a rare and acute severe adverse reaction to drugs, characterised by massive apoptosis and widespread epidermal and mucosal detachment. Although no gold standard therapy exists, human i.v. immunoglobulins have recently been described as an effective treatment for this disease. We report a case of phenobarbital-induced TEN in a 59-year-old white woman where the epidermal detachment stopped 48 h after beginning the etanercept treatment with complete healing after 20 days. To the best of our knowledge, this is only the second reported case of TEN successfully treated with etanercept.