Activation of the granulocyte-monocyte colony stimulating factor gene in acute myeloid leukaemia cells is not related to gene rearrangement
- Resource Type
- Authors
- Flavio Falcinelli; Marina Onorato; Raffaella Ciurnelli; Patrice Mannoni; Jean Gabert; Franca Falzetti; Massimo F. Martelli; Antonio Tabilio
- Source
- Leukemia Research. 15:957-961
- Subject
- Gene Rearrangement
Macrophage colony-stimulating factor
Cancer Research
Monocyte
Structural gene
Granulocyte-Macrophage Colony-Stimulating Factor
Hematology
Gene rearrangement
Biology
Colony-stimulating factor
Gene Expression Regulation, Neoplastic
Leukemia, Myeloid, Acute
Granulocyte macrophage colony-stimulating factor
medicine.anatomical_structure
Genes
Oncology
hemic and lymphatic diseases
Immunology
medicine
Humans
Colony-Stimulating Factor Gene
RNA, Messenger
RNA, Neoplasm
Autocrine signalling
medicine.drug
- Language
- ISSN
- 0145-2126
Several reports have documented that leukaemic blasts produce a number of cytokines among them the granulocyte-monocyte colony stimulating factor (GM-CSF). We analysed the structure of the gene that codes for GM-CSF in 44 acute myeloid leukaemia (AML) cases in an attempt to establish whether the autocrine production of GM-CSF was due to a structural gene alteration. No structural alteration was detected in the GM-CSF gene in any of the 44 cases studied. We, therefore, conclude that the autocrine production of GM-CSF by leukaemia blasts is not dependent on gene rearrangement.