New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1
- Resource Type
- Authors
- Lucía Morales-Cacho; Federico González-Pozas; Marina Vogel-González; Joan Domingo-Reinés; Verónica Ramos-Mejía; Verónica Ayllón; Rosa Montes
- Source
- Stem Cell Research, Vol 19, Iss, Pp 1-5 (2017)
- Subject
- 0301 basic medicine
Pluripotent Stem Cells
Down syndrome
Oncogene Proteins
Oncogene Proteins, Fusion
Genetic Vectors
Chromosomal translocation
Biology
Models, Biological
Cell Line
03 medical and health sciences
Leukemia, Megakaryoblastic, Acute
medicine
Humans
Induced pluripotent stem cell
Child
lcsh:QH301-705.5
Medicine(all)
Oncogene
General Medicine
Cell Biology
medicine.disease
Embryonic stem cell
Haematopoiesis
Leukemia
030104 developmental biology
lcsh:Biology (General)
Immunology
Cancer research
Biomarkers
Transcription Factors
Developmental Biology
- Language
- ISSN
- 1873-5061
Pediatric Acute Megakaryoblastic Leukemia not associated to Down Syndrome (non-DS AMKL) is a rare disease with a dismal prognosis. Around 15% of patients carry the chromosomal translocation t(1;22) that originates the fusion oncogene RBM15-MKL1, which is linked to an earlier disease onset (median of 6 months of age) and arises in utero. Here we report the generation of two hPSC cell lines constitutively expressing the oncogene RBM15-MKL1, resulting in an increased expression of known RBM15-MKL1 gene targets. These cell lines represent new disease models of pediatric AMKL to study the impact of the RBM15-MKL1 oncogene on human embryonic hematopoietic development.