Purpose: To assess the level of adherence with long-term glaucoma therapy at a tertiary care center,and to correlate the factors associated with non-compliance. Study design: Cross sectional study Place and Duration of Study Al-Shifa Trust Eye Hospital (ASTEH), Rawalpindi from October 2018 to February 2019 Methods: Two hundred patients presenting at the glaucoma clinic were recruited. An interview-based questionnaire was used to gather data. The dependent variable, adherence to long-term glaucoma treatment, was determinedand independent variables were;demographic profile, socio-economic variables, ocular and medical history, personal knowledge and understanding about disease and satisfaction level of the patient. The data was analyzed using SPSS version 24. Descriptive analysiswas followed by Inferential Statistics. To determine any association between independent and outcome variables, chi-square test was applied. All inferential statistics were based on a 5% significance value. Results:A high rate (30%) of non-compliance was found. A significant correlation was present between chief complaints of patients with compliance to medication (p