Hypothermia Regulates Insulin-like Growth Factor 1 Gene Expression in PC12 Cells
- Resource Type
- Authors
- Eun Ryeong Lee; Kisang Kwon; Seung Whan Kim; Kweon Yu; Bo-Kyung Yoo; O-Yu Kwon
- Source
- Biomedical Science Letters. 23:39-43
- Subject
- medicine.medical_specialty
medicine.medical_treatment
Growth factor
Ischemia
General Medicine
Hypothermia
medicine.disease
03 medical and health sciences
Insulin-like growth factor
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
chemistry
030225 pediatrics
Internal medicine
Gene expression
medicine
Lithium chloride
medicine.symptom
030217 neurology & neurosurgery
- Language
- ISSN
- 2288-7415
In this study, we evaluated the effects of various hypothermic conditions (32℃), including lithium chloride treatment, on insulin-like growth factor 1 (IGF-1) gene expression in PC12 cells. The results show that short-term hypothermic treatment ( 1 day). Repeated switching between normal temperature and hypothermia every 2 h increased IGF-1 gene expression approximately 3-4-fold. These findings indicate that hypothermia dynamically regulates IGF-1 gene expression. This study could be helpful for the development of treatment and diagnostic strategies for ischemia.