Site-Specific Cleavage of Insulin-Like Growth Factor II mRNAs
- Resource Type
- Authors
- P. Elly Holthuizen; Erwin L. van Dijk
- Source
- Endocrine Updates ISBN: 9781441949356
- Subject
- Cleavage stimulation factor
Messenger RNA
Cleavage factor
Chemistry
Growth factor
medicine.medical_treatment
Endoribonuclease
medicine
Protein biosynthesis
RNA
Cleavage and polyadenylation specificity factor
Cell biology
- Language
Insulin-like growth factor II (IGF-II) is a protein involved in growth and differentiation of numerous cell types. Because of the importance of IGF-II in many different processes, various regulatory mechanisms are available in the cell to control IGF-II protein synthesis, reflecting the vital importance of fine tuning and rapid regulation of IGF-II mRNA levels and IGF-II protein amount. One such mechanism is the site-specific endonucleolytic cleavage of IGF-II mRNAs, which will be described in this chapter. The role of an RNA-binding protein that is associated with the highly structured RNA will be discussed as well as the requirements for recognition of the IGF-II mRNA by an endoribonuclease.