Advanced glycation end products (AGE) are biomarkers for metabolic stress and can be detected in skin collagen non-invasively via skin intrinsic fluorescence techniques (SIF). AGE have been linked to complications in T1D and to mortality in both hemodialysis and type 2 diabetes patients. However, the relationship of SIF scores and mortality in T1D is unknown. This study examined the association of SIF scores to all-cause mortality in T1D. Participants were identified from the Pittsburgh Epidemiology of Diabetes and Complications study, a cohort of individuals diagnosed with childhood-onset T1D from 1950-80. SIF score was measured with the SCOUT DS® device in the year 2003-04 (baseline analytic year) in a convenience sample of 112 participants [mean years of age= 48.9 +/- (7.3), HbA1c=7.6% +/- (1.5), cumulative glycemic exposure over lifetime, or, A1c months=1095.9 +/- (495.2) diabetes duration in years=38.3 +/- (7.3)]. Vital status was assessed as of 12/10/2018, up to which 18 mortality events occurred. Univariately, compared to those who survived, the deceased had longer diabetes duration (p Disclosure E.L. Tomaszewski: None. T.J. Orchard: Consultant; Self; Boehringer Ingelheim International GmbH. M.S. Hawkins: None. T. Songer: Employee; Spouse/Partner; Boehringer Ingelheim Pharmaceuticals, Inc. J.D. Maynard: Consultant; Self; VisionQuest Biomedical LLC. Employee; Self; Avisa Pharma Inc. T. Costacou: None. Funding National Institutes of Health (DK34818); Rossi Memorial Fund