MECHANISMS OF HEMOLYSIS IN PATIENTS WITH HEART VALVE PROSTHESES
- Resource Type
- Authors
- Jon Dale; Knut Rasmussen; Erik Myhre
- Source
- Acta Medica Scandinavica. 189:105-107
- Subject
- medicine.medical_specialty
Erythrocytes
Aortic Valve Insufficiency
Hemolysis
Mechanical components
Valvular disease
Internal medicine
Internal Medicine
medicine
Humans
In patient
cardiovascular diseases
Heart valve
Prosthetic heart
L-Lactate Dehydrogenase
business.industry
Mitral Valve Insufficiency
medicine.disease
Turbulent blood flow
Surgery
Intravascular hemolysis
medicine.anatomical_structure
Heart Valve Prosthesis
cardiovascular system
Cardiology
business
- Language
- ISSN
- 0001-6101
Intravascular hemolysis was studied in a large, non-selected series of patients with aortic and mitral valvular disease or valve prostheses in order to clarify the mechanisms of the erythrocyte destruction. Hemolysis was slight in unoperated patients, even in cases with severe valvular disease. The degree of erythrocyte destruction in operated patients was mainly determined by the design and material of the prostheses, whereas it was similar in cases with aortic and mitral valves replaced. Our data suggest that the hemolysis in patients with prosthetic heart valves mainly is due to crushing of erythrocytes by the mechanical components of the prostheses, turbulent blood flow probably being a rather unimportant factor.