Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules
- Resource Type
- Authors
- Miguel M. Lino; Vitor Francisco; Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Lino Ferreira
- Source
- Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Bioconjugate Chemistry
- Subject
- Polymers
Ultraviolet Rays
Biomedical Engineering
Pharmaceutical Science
Nanoparticle
Bioengineering
macromolecular substances
02 engineering and technology
Conjugated system
01 natural sciences
Cell activity
Animals
Humans
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Pharmacology
chemistry.chemical_classification
Photolysis
010405 organic chemistry
Biomolecule
Organic Chemistry
technology, industry, and agriculture
Proteins
respiratory system
021001 nanoscience & nanotechnology
Polymeric nanoparticles
Small molecule
0104 chemical sciences
Cross-Linking Reagents
chemistry
Pharmaceutical Preparations
Delayed-Action Preparations
Biophysics
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Nanoparticles
Muramidase
0210 nano-technology
Intracellular
Biotechnology
- Language
- English
We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.