Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy
- Resource Type
- Authors
- Wilson, David; Abbotts, R; Jewell, R; Nsengimana, J; Maloney, DJ; Simeonov, A; Seedhouse, C; Elliott, F; Laye, J; Walker, C; Jadhav, A
- Source
- Wilson, David; Abbotts, R; Jewell, R; Nsengimana, J; Maloney, DJ; Simeonov, A; et al.(2014). Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9kx1m5gc
- Subject
- Language
- English
Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activi