Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
- Resource Type
- Authors
- Charles J. Eyermann; Janelle Comita-Prevoir; Brian Noonan; Elise Gorseth; Bolin Geng; Peter Doig; Gloria Anne Breault; Randy Petrichko
- Source
- Bioorganic & Medicinal Chemistry Letters. 18:6100-6103
- Subject
- Tertiary amine
Stereochemistry
Gram-positive bacteria
Clinical Biochemistry
Pharmaceutical Science
Microbial Sensitivity Tests
Muri
Gram-Positive Bacteria
Biochemistry
Structure-Activity Relationship
Drug Discovery
medicine
Combinatorial Chemistry Techniques
Glutamate racemase
Molecular Biology
Amino Acid Isomerases
Antibacterial agent
Molecular Structure
biology
Chemistry
Pteridines
Organic Chemistry
biology.organism_classification
Anti-Bacterial Agents
Enzyme inhibitor
biology.protein
Molecular Medicine
Antibacterial activity
Pteridine
medicine.drug
- Language
- ISSN
- 0960-894X
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.