Fertility Preservation in Endometriosis Patients: Anti-Müllerian Hormone Is a Reliable Marker of the Ovarian Follicle Density
- Resource Type
- Authors
- Daniela Toniolo; Stefano Ferrari; Gianluca Taccagni; Caterina Barbieri; Paola Panina-Bordignon; Elisabetta Garavaglia; Massimo Candiani; Cinzia Sala; Michela Traglia
- Source
- Frontiers in Surgery, Vol 4 (2017)
Frontiers in Surgery
- Subject
- 0301 basic medicine
medicine.medical_specialty
endocrine system
endocrine system diseases
fertility preservation
follicle density
Endometriosis
lcsh:Surgery
ovarian reserve
03 medical and health sciences
0302 clinical medicine
Follicular phase
medicine
Ovarian tissue cryopreservation
Fertility preservation
Ovarian follicle
Ovarian reserve
Original Research
Gynecology
030219 obstetrics & reproductive medicine
biology
ovarian tissue cryopreservation
business.industry
Anti-Müllerian hormone
lcsh:RD1-811
medicine.disease
female genital diseases and pregnancy complications
030104 developmental biology
medicine.anatomical_structure
anti-Müllerian hormone
biology.protein
Surgery
Folliculogenesis
business
- Language
- English
Objective To analyze the ovarian reserve via measurement of follicular density and anti-Müllerian hormone (AMH) in endometriosis patients participating to a clinical program of cortical ovarian cryopreservation. Design Retrospective analysis of serum AMH levels and prospective investigation of ovarian follicle number. Setting University Hospital. Patient(s) Two hundred and two women with endometriosis and 400 controls. Intervention(s) Blood samples and ovarian biopsies. Main outcome measure(s) Correlation of serum AMH levels and the number of non-growing follicles in the biopsied cortical tissues in endometriosis and control subjects, including age, type of AMH kit, and the laboratory performing the analysis as covariates. Result(s) AMH levels were shown to decrease with age in untreated endometriosis patients (P