Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
- Resource Type
- Authors
- Pavan S. Upadhyayula; Michael G Argenziano; Jeffrey N. Bruce; Peter Canoll; Eleonora F Spinazzi
- Source
- Pharmaceutics, Vol 13, Iss 39, p 39 (2021)
Pharmaceutics
- Subject
- Pharmaceutical Science
lcsh:RS1-441
Review
Single Center
Blood–brain barrier
lcsh:Pharmacy and materia medica
03 medical and health sciences
0302 clinical medicine
topotecan
Glioma
glioma
Parenchyma
convection enhanced delivery
Medicine
business.industry
fungi
glioblastoma
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
Topotecan
Convection-Enhanced Delivery
business
030217 neurology & neurosurgery
medicine.drug
Glioblastoma
- Language
- English
- ISSN
- 1999-4923
A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma.