DruGeVar: an online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics
- Resource Type
- Authors
- Elisavet Daki; Eleni Dalabira; Theodora Katsila; Emmanouil Viennas; Angeliki Komianou; George P. Patrinos; Konstantinos Poulas; Giannis Tzimas; Marina Bartsakoulia
- Source
- Public Health Genomics
- Subject
- Drug
Genetic Markers
Databases, Factual
Drug-Related Side Effects and Adverse Reactions
media_common.quotation_subject
Genomics
Bioinformatics
Online Systems
Efficacy
Medicine
Humans
Drug toxicity
Gene
Genetics (clinical)
media_common
Internet
business.industry
Public Health, Environmental and Occupational Health
Genomic biomarkers
3. Good health
Pharmacogenetics
Pharmacogenomics
business
Software
- Language
- ISSN
- 1662-8063
Background/Aims: Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels - approved by regulatory agencies - and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists. Methods: We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics. Results and Conclusions: A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases.