FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma
- Resource Type
- Authors
- Hanna, Gött; Eberhard, Uhl
- Source
- International Journal of Molecular Sciences. 23:8675
- Subject
- Lung Neoplasms
Organic Chemistry
General Medicine
Catalysis
Computer Science Applications
Inorganic Chemistry
Humans
Receptor, Fibroblast Growth Factor, Type 3
Oncogene Fusion
Gene Fusion
Physical and Theoretical Chemistry
Glioblastoma
Microtubule-Associated Proteins
Molecular Biology
Spectroscopy
- Language
- ISSN
- 1422-0067
Oncogenic fusion genes have emerged as successful targets in several malignancies, such as chronic myeloid leukemia and lung cancer. Fusion of the fibroblast growth receptor 3 and the transforming acidic coiled coil containing protein—FGFR3-TACC3 fusion—is prevalent in 3–4% of human glioblastoma. The fusion protein leads to the constitutively activated kinase signaling of FGFR3 and thereby promotes cell proliferation and tumor progression. The subgroup of FGFR3-TACC3 fusion-positive glioblastomas presents with recurrent clinical and histomolecular characteristics, defining a distinctive subtype of IDH-wildtype glioblastoma. This review aims to provide an overview of the available literature on FGFR3-TACC3 fusions in glioblastoma and possible implications for actual clinical practice.