Brain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrier
- Resource Type
- Authors
- Yu. A. Uspenskaya; A. V. Morgun; E. D. Osipova; S. K. Antonova; A. B. Salmina
- Source
- Fundamental and Clinical Medicine. 4:83-94
- Subject
- 0301 basic medicine
Ependymal Cell
Cilium
Neurodegeneration
Neurogenesis
Central nervous system
Biology
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
medicine
Functional activity
Neuroscience
030217 neurology & neurosurgery
- Language
- ISSN
- 2542-0941
2500-0764
Here we review the physiology of brain ependymocytes which produce cerebrospinal fluid, regulate neurogenic niches, and contribute to neurogenesis in health and disease. We particularly focus on cilia as these organelles are pivotal to ensure the normal functioning of ependymocytes. The functional activity of ependymocytes is largely defined by their localisation in the central nervous system. Further studies of ependymal cell biology are required to better understand the mechanisms of neurological disorders and to discover novel therapeutic strategies aimed at correcting neurodegeneration and aberrant development of the brain.