This chapter traces the history of modern meditation research. Meditation is conceptualized primarily as a seated practice for systematically training attention. Historically present in every major religion, meditation was traditionally used for spiritual purposes and usually accompanied by ancillary practices, such as spiritual fellowship. This chapter traces the dynamics and evolving interplay between dominant conceptions and forms of meditative practices under scientific study, as well as critiques of those conceptions, research questions, study designs, measurement instruments, and public reception and application. It describes how developments in each of these spheres have at different times opened up new lines of research, sometimes transforming other dimensions of ongoing research and practice. For the past fifty years, modern meditation research has progressed through partly overlapping periods that emphasized physiological measurement and secular adaptations; links to numerous health and well-being outcomes; emphasis on a sui generis psychosocial goal (mindfulness); advances in physiological and questionnaire-based empirical measurement; expansion of public, corporate, and governmental interest; increased concerns about abandonment of ethical bases and cultural context; and initial moves toward greater inclusiveness and integration of diverse methods and traditional perspectives.