Markers of lipid peroxidation and antioxidant status in the serum and saliva of patients with active Crohn disease
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Adult Male medicine.medical_specialty Saliva Antioxidant medicine.medical_treatment medicine.disease_cause Pathogenesis Lipid peroxidation Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Crohn Disease Increased oxidative stress has been implicated in the pathogenesis of Crohn disease (CD). Except for C‑reactive protein (CRP), good biological markers of CD activity are lacking. We aimed to investigate the diagnostic usefulness of selected markers of oxidative stress in the serum and saliva of patients with active and inactive CD. A total of 58 patients with confirmed CD (32 with active CD, 26 with inactive CD, and 26 healthy controls) were prospectively enrolled to the study. The markers examined were malondialdehyde (MDA), ferric reducing ability of plasma (FRAP), reduced glutathione (GSH), and catalase (CAT). MDA levels were higher in the serum and saliva of patients with active CD than in those with inactive CD and controls and were positively correlated with the Crohn’s Disease Activity Index (r = 0.8, P <0.001) and CRP (P <0.001). Serum and saliva antioxidant indicators (FRAP and GSH) were decreased in both CD groups compared with controls and were negatively correlated with clinical activity and inflammation (FRAP, r = -0.5, P <0.001 GSH, r = -0.5, P <0.001 and CAT, r = -0.5, P <0.001). The increased lipid peroxidation and decreased antioxidant activity in serum and saliva confirm that CD patients are under oxidative stress. The positive correlations of MDA with the clinical activity and inflammation, as well as the comparison of the receiver operating characteristic curves for MDA and CRP, suggest that MDA could be a good diagnostic marker of CD Malondialdehyde Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Inflammation saliva business.industry Crohn disease lipid peroxidation Glutathione Middle Aged Catalase Ferric reducing ability of plasma Oxidative Stress C-Reactive Protein Endocrinology chemistry Female Lipid Peroxidation business serum Biomarkers 030217 neurology & neurosurgery Oxidative stress - Language
- English