New dosimetric parameters to predict ano-rectal toxicity during radiotherapy treatment
- Resource Type
- Authors
- Antonella, Sanfratello; Davide, Cusumano; Antonio, Piras; Luca, Boldrini; Andrea, D'Aviero; Piero, Fricano; Marco, Messina; Marina, Vaglica; Daniele, Galanti; Massimiliano, Spada; Guido, Martorana; Goffredo, Arena; Tommaso, Angileri; Antonino, Daidone
- Source
- Physica Medica. 99:55-60
- Subject
- Rectal Neoplasms
Quality of Life
Rectum
Biophysics
Humans
General Physics and Astronomy
Proctitis
Radiotherapy Dosage
Radiology, Nuclear Medicine and imaging
General Medicine
Radiation Injuries
Retrospective Studies
- Language
- ISSN
- 1120-1797
Radiotherapy is essential in the treatment of locally advanced rectal cancer. Side effects of radiotherapy in the treatment of rectal cancer have a great effect on quality of life. The aim of this retrospective study is to evaluate the correlation between dosimetric parameters and acute toxicity in rectal cancer patients.We analyzed the Dose Volume Histogram parameters for both the target structures and the Organs at risk of 89 patients. A dedicated statistical analysis was performed for all the acute toxicities showing a frequency rate higher than 20%. A linear logistic regression model was elaborated using the variable showing the highest level of significance at the univariate analysis.The occurrence of proctitis was significantly correlated with three dosimetric parameters: D98% of low ano-rectum, DTwo dose constraints were elaborated: D98%33.5 Gy for low ano rectum to prevent grade 2 acute toxicity and D98%25 Gy for low ano-rectum wall to prevent proctitis (grade 1 or superior).