Dentate nucleus signal intensity changes on T1-weighted MRI after repeated administrations of linear and macrocyclic gadolinium-based contrast agents: a pediatric intraindividual case-control study
- Resource Type
- Authors
- Kerem Ozturk; David Nascene
- Source
- Acta Radiologica. 63:914-922
- Subject
- Gadolinium DTPA
media_common.quotation_subject
Gadolinium
Contrast Media
chemistry.chemical_element
Gadobutrol
Gadolinium-based Contrast Agent
Organometallic Compounds
medicine
T1 weighted
Humans
Contrast (vision)
Radiology, Nuclear Medicine and imaging
Child
Retrospective Studies
media_common
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
General Medicine
Magnetic Resonance Imaging
Dentate nucleus
Cerebellar Nuclei
chemistry
Case-Control Studies
Signal intensity
Nuclear medicine
business
medicine.drug
- Language
- ISSN
- 1600-0455
0284-1851
Background An association between consecutive administrations of macrocyclic gadolinium-based contrast agent (mcGBCA) gadobutrol and linear (L)-GBCA gadopentetate dimeglumine and gadolinium retention in the pediatric brain remains incompletely understood. Purpose To compare signal intensity (SI) changes in the dentate nucleus (DN) on unenhanced T1-weighted imaging (T1WI) in children who obtained mcGBCA gadobutrol with those who had previously received L-GBCA gadopentetate dimeglumine. Material and Methods This retrospective study included 27 children who received L-GBCA gadopentetate dimeglumine followed by mcGBCA gadobutrol and two different control groups matched for age and sex for both periods, each involving 27 individuals with no GBCA administration from January 2010 to January 2020. DN-to-middle cerebellar peduncle (MCP) SI ratios on T1WI were determined. A repeated-measures ANOVA was performed to compare the T1WI SI ratio between children exposed to GBCA in each of the two periods and controls. Pearson correlation analysis was conducted to determine any correlation between SI ratios and confounding parameters. Results T1WI SI ratio was significantly higher in those who had only L-GBCA (1.005±0.087) or subsequent mcGBCA gadobutrol (1.002±0.104) than in control groups 1 (0.927±0.041; PConclusion Previous administration of gadopentetate dimeglumine is associated with increased T1WI SI in the DN, while subsequent administration of gadobutrol does not demonstrate any additional SI increase in the pediatric brain.