4-Sulfonamidoanilide tertiary carbinols: A novel series of potassium channel openers
- Resource Type
- Authors
- T. Grant; C.A. Frank; Daniel Ray Mayhugh; James Roy Empfield; C.J. Ohnmacht; Jack H. Li
- Source
- Bioorganic & Medicinal Chemistry Letters. 7:775-778
- Subject
- chemistry.chemical_classification
medicine.drug_class
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Carboxamide
Haloalcohol
Biochemistry
Chemical synthesis
Potassium channel
Sulfonamide
chemistry
Drug Discovery
medicine
Molecular Medicine
Organic chemistry
Molecular Biology
- Language
- ISSN
- 0960-894X
Sulfonamides are viable replacements for the phenylsulfonyl and benzoyl moieties initially described for the anilide tertiary carbinol series of KATP potassium channel openers. The SAR of this new series and the synthetic chemistry employed to generate its members are described.