Studies of neutrophil production and turnover in grey collie dogs with cyclic neutropenia
- Resource Type
- Authors
- Sheldon M. Wolff; H. R. Kimball; S. B. Ward; D. C. Dale
- Source
- The Journal of clinical investigation. 51(8)
- Subject
- Male
medicine.medical_specialty
Periodicity
Myeloid
Neutrophils
Neutropenia
Tritium
Cyclic neutropenia
Leukocyte Count
Dogs
Internal medicine
hemic and lymphatic diseases
medicine
Animals
Dog Diseases
business.industry
Collie
General Medicine
Articles
Neutrophil production
medicine.disease
Myeloid proliferation
Hematopoietic Stem Cells
Hematopoiesis
Haematopoiesis
Endocrinology
medicine.anatomical_structure
Immunology
Diisopropyl fluorophosphate
Autoradiography
Female
Muramidase
business
medicine.drug
Agranulocytosis
Thymidine
- Language
- ISSN
- 0021-9738
A B S T R A C T 12 grey collie dogs had cyclic neutropenia with the neutropenia recurring at 11.8+0.1-day intervals. The recovery from neutropenia was accompanied by a single wave of myeloid proliferation, an increase in marrow myeloid-labeling indices, and an increase in serum muramidase levels. After recovery from neutropenia during the period when blood neutrophils (PMN) were normal or increased, marrow myeloid precursors became scarce. The decline in marrow precursors and marrow PMN reserves heralded the recurrence of neutropenia. Neither diisopropyl fluorophosphate (DF32P) leukokinetic studies nor the rate of development of neutropenia suggested shortened PMN survival as a mechanism for the neutropenia. These studies indicate that the cyclic neutropenia is due to a regularly recurring failure in PMN production.