Neural correlates of human somatosensory integration in tinnitus
- Resource Type
- Authors
- Cris P. Lanting; R. N. Eppinga; P. van Dijk; E. de Kleine
- Source
- Hearing Research, 267(1-2), 78-88. ELSEVIER SCIENCE BV
- Subject
- Adult
Male
Inferior colliculus
medicine.medical_specialty
INDUCED HEARING-LOSS
MULTISENSORY CONVERGENCE
Audiology
Somatosensory system
Cochlear nucleus
GUINEA-PIG
Tinnitus
stomatognathic system
Neural Pathways
otorhinolaryngologic diseases
medicine
Humans
Auditory system
Psychoacoustics
Aged
PRIMARY AUDITORY-CORTEX
medicine.diagnostic_test
ASSOCIATION CORTEX
Somatosensory Cortex
Middle Aged
COCHLEAR NUCLEUS
Inferior Colliculi
SUPERIOR TEMPORAL PLANE
Sensory Systems
GAZE-EVOKED TINNITUS
stomatognathic diseases
medicine.anatomical_structure
Jaw
Case-Control Studies
FMRI
Cerebellar vermis
Female
medicine.symptom
Functional magnetic resonance imaging
Psychology
Neuroscience
CEREBELLAR VERMIS
Brain Stem
- Language
- ISSN
- 0378-5955
Possible neural correlates of somatosensory modulation of tinnitus were assessed. Functional magnetic resonance imaging (fMRI) was used to investigate differences in neural activity between subjects that can modulate their tinnitus by jaw protrusion and normal hearing controls. We measured responses to bilateral sound and responses to jaw protrusion. Additionally we studied multimodal integration of somatosensory jaw protrusion and sound. The auditory system responded to both sound and jaw protrusion. Jaw responses were enhanced in the cochlear nucleus (CN) and the inferior colliculus (IC) in tinnitus patients. The responses of the auditory brain areas to jaw protrusion presumable account for the modulation of tinnitus as described by the patients. The somatosensory system responded to jaw protrusion and not to sound. These responses occurred both in subjects with tinnitus and controls. Unexpectedly, the cerebellum responded to sound in normal hearing subjects, but not in tinnitus patients. Together, these results provide a neurophysiological basis for the effect of jaw protrusion on tinnitus. (C) 2010 Elsevier B.V. All rights reserved.