Functional imaging of unilateral tinnitus using fMRI
- Resource Type
- Authors
- H Bartels; Cris P. Lanting; P. van Dijk; E. de Kleine
- Source
- Acta oto-Laryngologica, 128(4), 415-421
- Subject
- Inferior colliculus
Adult
Male
medicine.medical_specialty
genetic structures
Hearing loss
Audiology
PULSATILE TINNITUS
Auditory cortex
Severity of Illness Index
LATERALIZED TINNITUS
inferior colliculus
ACTIVATION
Hearing
medicine
otorhinolaryngologic diseases
Auditory system
Humans
auditory cortex
tinnitus
Aged
PRIMARY AUDITORY-CORTEX
central auditory system
Inferior Colliculi
medicine.diagnostic_test
business.industry
fMRI
Magnetic resonance imaging
General Medicine
Middle Aged
Prognosis
Magnetic Resonance Imaging
DORSAL COCHLEAR NUCLEUS
Functional imaging
medicine.anatomical_structure
Otorhinolaryngology
Acoustic Stimulation
Audiometry, Pure-Tone
Regression Analysis
Female
medicine.symptom
business
Tinnitus
Follow-Up Studies
- Language
- English
- ISSN
- 0001-6489
Conclusions. This article shows that the inferior colliculus plays a key role in unilateral subjective tinnitus. Objectives. The major aim of this study was to determine tinnitus-related neural activity in the central auditory system of unilateral tinnitus subjects and compare this to control subjects without tinnitus. Subjects and methods. Functional MRI (fMRI) was performed in 10 patients (5 males) with unilateral tinnitus (5 left-sided, 5 right-sided) and 12 healthy subjects (6 males); both groups had normal hearing or mild hearing loss. fMRI experiments were performed using a 3T Philips Intera Scanner. Auditory stimuli were presented left or right and consisted of dynamically rippled broadband noise with a sound pressure level of 40 or 70 dB SPL. The responses of the inferior colliculus and the auditory cortex to the stimuli were measured. Results. The response to sound in the inferior colliculus was elevated in tinnitus patients compared with controls without tinnitus.