Whole Blood Tissue Factor Procoagulant Activity Remains Detectable during Severe Aplasia following Bone Marrow and Peripheral Blood Stem Cell Transplantation
- Resource Type
- Authors
- Ronald R. Bach; Luke Dandelet; Muhit Ozcan; Robert P. Hebbel; Colleen T. Morton; Nigel S. Key; Arne Slungaard; Anna Solovey
- Source
- Thrombosis and Haemostasis. 85:250-255
- Subject
- Pathology
medicine.medical_specialty
business.industry
Hematology
Aplasia
Bone Marrow Aplasia
medicine.disease
Peripheral blood mononuclear cell
Tissue factor
medicine.anatomical_structure
Immunology
medicine
Peripheral Blood Stem Cell Transplantation
Bone marrow
Stem cell
business
Whole blood
- Language
- ISSN
- 2567-689X
0340-6245
SummaryUsing a novel whole blood assay, we recently demonstrated that tissue factor procoagulant activity (TF PCA) is present in normal individuals. Preliminary experiments suggested that this activity is localized in the mononuclear cell fraction. Postulating that whole blood TF PCA would therefore be undetectable when monocytes and neutrophils are absent from peripheral blood, we assayed TF PCA during the peri-transplant period in 15 consecutive patients undergoing allogeneic (n = 12) or autologous (n = 3) bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT). Baseline (pre-transplant) mean TF PCA was higher in patients compared to normal controls (P