Comparison of continuous wave and pulsed mode plasma polymerization of glycidol for storage‐stable coatings for biomolecule immobilization
- Resource Type
- Authors
- Argha Chakraborty; Marek Jasieniak; Bryan R. Coad; Hans J. Griesser
- Source
- Plasma Processes and Polymers.
- Subject
- epoxide plasma polymer aging
Polymers and Plastics
glycidol plasma polymer
plasma polymerization
antimicrobial surface analysis
biomaterial associated infections
covalent immobilization
Condensed Matter Physics
antifungal coatings
- Language
- ISSN
- 1612-8869
1612-8850
Plasma polymers from glycidol vapors are of interest for direct covalent grafting of molecules bearing amine or thiol groups. The question of whether pulsed plasma operation might lead to a higher surface density of epoxide groups and a higher density of grafted molecules is studied using the antifungal drug caspofungin. X-ray photoelectron spectroscopy and Time of flight-secondary ions mass spectrometry analysis followed by caspofungin grafting revealed that both continuous wave and pulsed plasmas led to surface epoxides but with higher densities upon pulsing. Investigations into stability suggested that glycidol plasma polymer coatings were still able to immobilize caspofungin after 2 years of storage, making them suitable for applications where grafting of molecules needs to be done immediately before usage of a device. Refereed/Peer-reviewed