We report the synthesis, crystal structure and physical properties of a new layered oxypnictide Ba 2 Ti 2 Cr 2 As 4 O, which is isostructural to the Ba 2 Ti 2 Fe 2 As 4 O superconductor. Electrical resistivity and magnetic susceptibility demonstrate that this new compound is of metallic conduction with an anomaly occurring at 350 K, which is probably due to an antiferromagnetic (AFM) transition in the [Cr 2 As 2 ] 2− layers. The absence of the charge- or spin-density wave (CDW/SDW) instability in the [Ti 2 As 2 O] 2− layers was ascribed to the mixed occupation of Cr in the Ti sublattice. No superconductivity is observed down to 2 K.