Phenotype and pathological significance of MCAM+ (CD146+) T cell subset in psoriatic arthritis
- Resource Type
- Authors
- Siba P. Raychaudhuri; Christine Abria; Smriti K. Raychaudhuri
- Source
- Molecular Biology Reports. 48:6787-6796
- Subject
- Chemistry
Cell adhesion molecule
Cell
Inflammation
General Medicine
CD11a
Pathogenesis
medicine.anatomical_structure
Genetics
Cancer research
medicine
CD146
Synovial fluid
medicine.symptom
Molecular Biology
CD8
- Language
- ISSN
- 1573-4978
0301-4851
BackgroundCD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146+IL-17+memory T cells in PsA synovium and studied the association of CD146 expression and CD4+IL-17+activated memory (CD11a+CD45RO+) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients.MethodsHi-D FACS studies were done to identify IL-17 in CD4+CD146+CD45RO+and CD8+CD146+CD45RO+T cells.ResultsWe observed that effector CD146+(MCAM+) T cells are enriched at the synovial inflammation site in PsA.ConclusionAs CD146+T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM+pathologic cells are critical for the disease process of PsA.