Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody
- Resource Type
- Authors
- Christa Goodell; Troy James Kaiser; Marc Allan Eichmeyer; Wesley Scott Johnson; Marika Genzow
- Source
- Influenza and Other Respiratory Viruses
- Subject
- 0301 basic medicine
Pulmonary and Respiratory Medicine
040301 veterinary sciences
Epidemiology
Swine
medicine.medical_treatment
viruses
Heterologous
Passive immunity
piglets
Viral Nonstructural Proteins
medicine.disease_cause
Antibodies, Viral
Vaccines, Attenuated
live attenuated influenza virus vaccine
Virus
virus shedding
0403 veterinary science
03 medical and health sciences
Immune system
Influenza A Virus, H1N1 Subtype
Orthomyxoviridae Infections
Influenza A virus
medicine
influenza A virus
Animals
Viral shedding
Administration, Intranasal
business.industry
Influenza A Virus, H3N2 Subtype
Vaccination
Public Health, Environmental and Occupational Health
04 agricultural and veterinary sciences
Original Articles
Virology
030104 developmental biology
Infectious Diseases
Animals, Newborn
Influenza Vaccines
Nasal administration
Original Article
Female
business
maternally derived antibodies
Immunity, Maternally-Acquired
- Language
- English
- ISSN
- 1750-2659
1750-2640
Background Influenza A virus in swine (IAV-S) causes an acute respiratory disease of swine which results in great economic losses in pig production. Major control strategies include the use of killed vaccines (KV) in breeding females to confer passive immunity to their offspring. A bivalent H1N1 and H3N2 NS1-truncated live attenuated IAV-S vaccine have recently become available, which showed promising results in young pigs. Objective The aim of this study was to investigate the effect of an intranasal vaccination of newborn pigs with or without maternally derived antibodies (MDA) on virus shedding (via nasal swabs tested by virus isolation). Methods The study was performed as intratracheal challenge experiments with either a heterologous H1N2 or H3N2 viruses. Results and conclusion The results of this study showed a significant decrease in the incidence and duration of shedding viable virus for vaccinated newborn piglets with or without MDA, providing strong evidence that intranasal vaccination is overcoming passively acquired maternal immunity. This study indicates that intranasal vaccination with a truncated NS1 live attenuated IAV-S vaccine of newborn piglets with maternal antibodies can be a valuable tool for reducing the prevalence of heterologous H1N2 and H3N2 IAV-S in pig herds.