Bioactive dipeptide from potato protein hydrolysate combined with swimming exercise prevents high fat diet induced hepatocyte apoptosis by activating PI3K/Akt in SAMP8 mouse
- Resource Type
- Authors
- Pei-Fang Lai; Chih Yang Huang; Tsung-Jung Ho; Cecilia Hsuan Day; Yu-Lan Yeh; Ray-Jade Chen; Rathinasamy Baskaran; V. Vijaya Padma; Chia-Hua Kuo; Chin-Hu Lai
- Source
- Molecular Biology Reports. 48:2629-2637
- Subject
- 0301 basic medicine
Senescence
medicine.medical_specialty
Cell Survival
Protein Hydrolysates
Apoptosis
Diet, High-Fat
Hydrolysate
Mice
Phosphatidylinositol 3-Kinases
03 medical and health sciences
0302 clinical medicine
Physical Conditioning, Animal
Internal medicine
Nonalcoholic fatty liver disease
Genetics
medicine
Animals
Molecular Biology
Protein kinase B
Swimming
PI3K/AKT/mTOR pathway
Solanum tuberosum
business.industry
food and beverages
nutritional and metabolic diseases
Dipeptides
General Medicine
medicine.disease
Obesity
030104 developmental biology
Endocrinology
030220 oncology & carcinogenesis
Toxicity
Hepatocytes
business
Proto-Oncogene Proteins c-akt
Biomarkers
- Language
- ISSN
- 1573-4978
0301-4851
Obesity in aged population have surges the occurrence of various metabolic disorders including Nonalcoholic fatty liver disease (NAFLD). Apoptosis in the liver is one of the causative factors for NAFLD-induced liver damage. Plants derived bioactive peptides have been shown as an alternative treatment approach for the treating NAFLD due to its less toxicity. Moderate exercise has been reported to improve cellular physiological function prevent age associated metabolic disorders. In the present study, we evaluate the effects of bioactive dipeptide (IF) derived from alcalase potato-protein hydrolysates and swimming exercise in preventing High Fat Diet (HFD)-induced liver damage in senescence accelerated mouse-prone 8 (SAMP8) mice model. Mouse were fed with HFD for 6 weeks followed by oral IF administration or swimming exercise and both for 8 weeks. HFD induces significant structural changes in liver of HFD fed SAMP8 mouse. Both IF administration and exercise prevent the structural abnormalities induced by HFD, however, combined IF treatment and exercise offer better protection. Combined IF treatment and exercise activate PI3K/Akt cell survival protein and effectively inhibit Fas-FADD-induced apoptosis in HFD fed aged mouse. Oral supplementation of bioactive peptide IF combined with moderate swimming exercise effectively alleviate HFD-induced hepatic injury in aged mice.