Poly(ADP-ribose) Polymerase-1 is required for hepatocyte proliferation and liver regeneration in mice
- Resource Type
- Authors
- Shu Yan; Chenhui Ju; Chang Liu; Xiaoxiang Mao; Yilong Wang; Kai Huang; Minglu Liang
- Source
- Biochemical and Biophysical Research Communications. 511:531-535
- Subject
- 0301 basic medicine
Poly ADP ribose polymerase
Cell
Poly (ADP-Ribose) Polymerase-1
Biophysics
Biochemistry
Mice
03 medical and health sciences
0302 clinical medicine
PARP1
medicine
Animals
Hepatectomy
Cyclin D1
Cyclin B1
Molecular Biology
Cell Proliferation
Mice, Knockout
chemistry.chemical_classification
Cell Biology
Cell cycle
Liver regeneration
Liver Regeneration
Cell biology
030104 developmental biology
Enzyme
medicine.anatomical_structure
Gene Expression Regulation
chemistry
030220 oncology & carcinogenesis
Hepatocyte
Knockout mouse
Hepatocytes
- Language
- ISSN
- 0006-291X
Liver regeneration is an orchestrated cellular response and the mechanisms underlying it have been extensively studied using the partial hepatectomy (PHx) model. Poly(ADP-Ribose) Polymerase-1 (PARP1) is a common enzyme for post-translational modification of proteins. Here, we aimed to determine the role of PARP1 in liver regeneration. We found that PARP1 activity was strongly associated with hepatocyte proliferation after PHx. PARP1 knockout mice showed impaired liver recovery and suppressed hepatocyte proliferation after PHx. Mechanistically, PARP1 knockout repressed YAP activity and inhibited expression of cell cycle-associated proteins in liver tissues. Therefore, our findings highlight specialized roles for PARP1 in regulating hepatocytes proliferation and liver regeneration.