Hepatic expansion of virus-specific CD8
- Resource Type
- Authors
- Huaizhou, Wang; Beiying, Wu; Lei, Li; Liang, Hu; Jiafei, Lin; Cen, Jiang; Gang, Cai; Qian, Shen
- Source
- Cellular immunology. 311
- Subject
- Adult
Immunosuppression Therapy
Male
Hepatitis B virus
CD8-Positive T-Lymphocytes
Middle Aged
Interleukin-10
Young Adult
Hepatitis B, Chronic
Liver
Cytokines
Humans
Female
Receptors, Immunologic
Cells, Cultured
Cell Proliferation
Signal Transduction
- Language
- ISSN
- 1090-2163
Similar to programmed death-1 (PD-1), B and T lymphocyte attenuator (BTLA) is a co-inhibitory molecule of the CD28 family. PD-1 is involved in T cell exhaustion during chronic viral infection. However, the role of BTLA in virus-specific T cells is poorly defined. Here we investigated the expression and function of BTLA in T cells from patients with chronic hepatitis B virus (HBV) infection. The phenotype of peripheral and intrahepatic HBV-specific T cells from 43 patients with chronic HBV infection was assessed by flow cytometry. Functional evaluation was analyzed by T cell expansion and cytokine secretion after different treatments. In chronic HBV patients, a subset of inefficient interferon-γ producing antigen-specific CD8