Management of malignant insulinoma
- Resource Type
- Authors
- C. Camps Herrero; M. Civera-Andrés; Carlos Sánchez-Juan; S. Navas-DeSolís; C. Caballero-Díaz; Juan Carlos Ferrer-García; Á. Merchante-Alfaro; V. Iranzo Gonzalez-Cruz; C. Morillas-Ariño
- Source
- CLINICAL & TRANSLATIONAL ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-FISABIO. Repositorio Institucional de Producción Científica
- Subject
- Adult
Male
Oncology
endocrine system
Cancer Research
medicine.medical_specialty
Endocrine Tumor
endocrine system diseases
Vasodilator Agents
education
Treatment outcome
Hypoglycemia
Internal medicine
medicine
Humans
Yttrium Radioisotopes
Everolimus
Islet cell tumors
Chemoembolization, Therapeutic
Glucocorticoids
Insulinoma
Aged
Retrospective Studies
Sirolimus
Radiotherapy
business.industry
General surgery
Diazoxide
Neuroendocrine pancreatic tumor
General Medicine
Middle Aged
medicine.disease
Malignant insulinoma
Pancreatic Neoplasms
Treatment Outcome
medicine.anatomical_structure
Female
Pancreas
business
Immunosuppressive Agents
medicine.drug
- Language
- ISSN
- 1699-3055
1699-048X
Malignant insulinoma is an infrequent functional endocrine tumor of the pancreas. Adequate therapy is a demanding challenge for oncologists and endocrinologists. To evaluate the results of multidisciplinary management of malignant insulinoma. Retrospective review of patients with malignant insulinoma treated from 1995 to 2011. Seven patients with malignant insulinoma were included: four males and three females; median age was 61.8 years (range 37-78). Six tumors were sporadic and one was diagnosed in a patient with a type 1 multiple endocrine neoplasia (MEN-1). Surgery was performed in six cases and one patient was considered unresectable. Hypoglycemias persisted in all cases and somatostatin analogs, glucocorticoids and diazoxide were used. Two patients received everolimus. Other techniques were chemoembolization and internal radiation therapy with yttrium-90. Successful liver transplant was done in the patient with MEN-1. Hypoglycemia management is complex and requires multiple therapies. Further evaluations will be necessary to determine the best treatment.