Introduction: Sleeve gastrectomy (SG) has become a technique in its own right although a selective or global indication remains controversial. The weight loss data at 5 years are heterogeneous. The aim of the study is to identify possible prognostic factors of insufficient weight loss after SG. Methods: A SG retrospective multicenter study of more than one year follow-up was performed. Failure is considered if EWL > 50%. Univariate and multivariate study of Cox regression were performed to identify prognostic factors of failure of weight loss at 1, 2 and 3 years of follow up. Results: A total of 1,565 patients treated in 29 hospitals are included. PSP per year: 70.58 +/- 24.7; 3 years 69.39 +/- 29.2; 5 years 68.46 +/- 23.1. Patients with EWL < 50 (considered failure): 17.1% in the first year, 20.1% at 3 years, 20.8% at 5 years. Variables with influence on the weight loss failure in univariate analysis were: BMI > 50 kg/m(2), age > 50 years, DM2, hypertension, OSA, heart disease, multiple comorbidities, distance to pylorus> 4 cm, bougie > 40 F, treatment with antiplatelet agents. The reinforcement of the suture improved results. In multivariate study DM2 and BMI are independent factors of failure. Conclusion: The SG associates a satisfactory weight loss in 79% of patients in the first 5 years; however, somevariablessuchasBMI > 50, age > 50, thepresenceofseveralcomorbidities, more than 5 cm section of the pylorus or bougie > 40 F can increase the risk of weight loss failure. (C) 2017 AEC. Published by Elsevier Espanna, S.L.U. All rights reserved.