Stress responses after treatment of hypercholesterolaemia with simvastatin
- Resource Type
- Authors
- D Neely; D.P. Nicholls; C. F. Stanford; I McDowell; M O'Kane; I. S. Young; N. Bell; A. M. Nugent
- Source
- Scopus-Elsevier
- Subject
- Adult
Male
medicine.medical_specialty
Simvastatin
Hypercholesterolemia
Physical exercise
Blood Pressure
Placebo
chemistry.chemical_compound
Adrenocorticotropic Hormone
Heart Rate
Stress, Physiological
Internal medicine
Heart rate
medicine
Humans
Pharmacology (medical)
cardiovascular diseases
Exercise physiology
Exercise
Hydrocortisone
Pharmacology
business.industry
Cholesterol
Anticholesteremic Agents
nutritional and metabolic diseases
Middle Aged
Endocrinology
Blood pressure
chemistry
Exercise Test
lipids (amino acids, peptides, and proteins)
Female
business
medicine.drug
Research Article
- Language
- English
In order to determine whether treatment of hyperlipidaemia with simvastatin impairs exercise stress responses and so may contribute to an excess of suicides and violent deaths, the effects of simvastatin 20 mg daily and placebo on exercise physiology were compared in 19 patients. After 6 weeks of treatment there was no evidence of reduced exercise capacity, or of reduced cortisol or catecholamine responses. It is concluded that treatment of hyperlipidaemia with an inhibitor of HMG-CoA reductase does not significantly modify stress responses, and so the explanation for a possible increase in non-cardiac mortality must be sought elsewhere.