Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan
- Resource Type
- Authors
- Roland Hubaux; Michel Salmon; Aline Chrétien; Céline Lancelot; Ah Young Park; J. Helen Fitton; Maureen Bourtembourg
- Source
- Dermatopathology, Vol 8, Iss 12, Pp 69-83 (2021)
Dermatopathology
Volume 8
Issue 2
Pages 12-83
- Subject
- 0301 basic medicine
Staphylococcus aureus
Periostin
medicine.disease_cause
Microbiology
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
fucoidan
Staphylococcus epidermidis
reconstructed human epidermis
Gene expression
lcsh:Dermatology
medicine
periostin
atopic dermatitis
biology
Chemistry
Fucoidan
Adhesion
Atopic dermatitis
lcsh:RL1-803
biology.organism_classification
medicine.disease
In vitro
body regions
030104 developmental biology
- Language
- ISSN
- 2296-3529
Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of Staphylococcus aureus. Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and may inhibit adhesion of pathogens. Fucoidan was assessed for effects on gene expression of an in vitro 3D model of atopic dermatitis. It was also assessed for inhibitory effects on the adhesion of bacteria onto 3D reconstructed skin. Fucoidan significantly altered gene expression in the atopic dermatitis model, and there was a trend to reduce periostin levels. Fucoidan significantly inhibited the adhesion of Staphylococcus aureus and Cutibacterium acnes but did not affect the adhesion of Staphylococcus epidermidis. Fucoidan may be a useful topical agent to assist in the management of atopic dermatitis.